Serotonin in tension headache.
نویسندگان
چکیده
Serotonin (5-hydroxytryptamine, 5-HT) is implicated in the pathogenesis of migraine; however, its role in tension headache has not yet been studied. The uptake of 5-HT by platelets in patients of tension headache was significantly higher compared with migraineurs as well as controls. The basal platelet 5-HT levels did not show a significant difference. The study implicates the role of serotonin in tension headache.
منابع مشابه
A non-selective (amitriptyline), but not a selective (citalopram), serotonin reuptake inhibitor is effective in the prophylactic treatment of chronic tension-type headache.
OBJECTIVES Although the tricyclic antidepressant amitriptyline is extensively used in the prophylactic treatment of chronic tension-type headache, only few studies have investigated the efficacy of this treatment and the results are contradictory. In addition, the new selective serotonin reuptake inhibiting antidepressants, which are widely used in depression and of potential value in pain mana...
متن کامل(citalopram), serotonin reuptake inhibitor is effective in the prophylactic treatment of chronic tension-type headache
Received 2 January 1996 and in revised form 18 March 1996 Accepted 22 March 1996 Abstract Objectives-Although the tricyclic antidepressant amitriptyline is extensively used in the prophylactic treatment of chronic tension-type headache, only few studies have investigated the efficacy of this treatment and the results are contradictory. In addition, the new selective serotonin reuptake inhibitin...
متن کاملH Ketanserin Binding in Tension-type Headache
Objective.—The present study was undertaken to investigate the alterations in platelet 5-HT 2 receptor binding in patients with tension-type headache. Background.—Serotonin (5-HT) has an important but complex role in pain modulation. The involvement of serotonin in tension-type headache has been investigated by studying serotonin in peripheral blood, but results have been inconclusive. There ar...
متن کاملPlasma serotonin in patients with chronic tension headaches.
Previous reports have suggested that platelet level of serotonin in chronic tension headache (CTH) is lower than in normal control subjects, and that there is continuous activation of platelets both in migraine and in CTH. In this study we compared platelet serotonin concentration in 95 patients with CTH, 166 patients with migraine and 35 normal control subjects. Mean platelet serotonin (ng/10(...
متن کاملTricyclic antidepressants and headaches: systematic review and meta-analysis
OBJECTIVE To evaluate the efficacy and relative adverse effects of tricyclic antidepressants in the treatment of migraine, tension-type, and mixed headaches. DESIGN Meta-analysis. DATA SOURCES Medline, Embase, the Cochrane Trials Registry, and PsycLIT. Studies reviewed Randomised trials of adults receiving tricyclics as only treatment for a minimum of four weeks. DATA EXTRACTION Frequency...
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ورودعنوان ژورنال:
- Journal of neurology, neurosurgery, and psychiatry
دوره 50 12 شماره
صفحات -
تاریخ انتشار 1987